From the early years of the colonization of southern Pennsylvania, Conococheague Creek and its tributaries played an important role in providing transportation routes into the region.
One can assume that these early settlers, as well as Native Americans living in the region, also fished the stream and its tributaries. I cannot say how the fishing was or what species may have been present then, but I can tell you that today the fishing remains good, especially for trout and smallmouth bass.
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